Hepatocellular carcinoma (HCC) could be detected early enough to apply curative treatment if patients at risk for HCC development are closely monitored under advanced surveillance strategies. The use of serum biomarkers lectin-reactive alpha-fetoprotein (AFP-L3) and des-gamma-carboxy prothrombin (DCP) in surveillance can improve your chances of detecting early HCC.
Early detection of HCC is crucial for the application of curative therapies and improving patient outcome. Since the underlying cause of HCC is usually identifiable, patients who are at-risk for HCC development are highly encouraged to enroll in HCC surveillance programs for early detection of HCC.
The quality of surveillance impacts the ability to find HCC at an early stage which is when curative treatment options are available.
Serological biomarkers AFP-L3 and DCP are associated with HCC development and elevated values for either of the biomarkers are early indicators that a patient with chronic liver disease will develop HCC. Several studies have shown that AFP-L3 and DCP increase before HCC is detectable by imaging. Therefore, adding the two biomarkers to a regular surveillance program such as AFP and ultrasound can help physicians identify HCC tumors earlier in at risk patients.
Please download “HCC Surveillance Algorithm” Brochure (pdf)”
The combined use of AFP-L3 and DCP tests is currently available and can be ordered with a single test code at most major reference laboratories in the United States. Laboratories can measure serum levels of AFP-L3 and DCP with a single serum sample on a single analyzer, μTASWako i30 [19,21]. The tests can also be ordered from Canada. For information on how to order the tests in Canada, please contact at Customer Service.