LDL Cholesterol

Special Features

• Direct method with no sample preparation
• Convenient, ready-to-use liquid type reagent
• No significant interference from serum components
• Suitable for automated analyzers

In recent years, in addition to total cholesterol, low density lipoprotein cholesterol (LDL-C) has become an important tool used to assess an individual risk of developing coronary heart disease (CHD) since a strong positive relationship between LDL-C concentration and the incidence of CHD exists. Thus, there has been substantial interest in LDL-C measurements, and most clinical laboratories routinely perform LDL-C analysis.

The currently accepted reference method is generally referred to as “beta quantification,”which involves ultracentrifugation. Because this method is labor intensive and technique dependent, it is not generally used for routine testing. The Friedewald formula is most commonly used for routine purposes. However, since the formula estimates the LDL-C level from measurements of total cholesterol, triglyceride and high density lipoprotein cholesterol (HDL-C), the LDL-C calculation depends on the accuracy and precision of the three measurements.

The Wako L-Type LDL-C assay is a homogeneous assay, which eliminates the preparatory steps or calculation, and thus, can be applied on automated analyzers. The L-Type LDL-C is an in vitro assay for the quantitative determination of LDL cholesterol in serum or plasma.

L-Type LDL-C Family Product Information